We study the effects of stress on the brain and behavior using zebrafish. Prolonged or severe exposure to stress hormones leads to behavioural dysfunctions. We are particularly interested in understanding how prolonged or severe exposure to stress hormones lead to behavioral dysfunctions.
Our current research centers around the key stress hormones produced by our body’s main stress response system, the Hypothalamo-Pituitary-Adrenal (HPA) axis. The HPA axis coordinates diverse aspects of the stress response in all vertebrates and the hormones produced by the HPA axis are remarkably conserved throughout vertebrate kingdom. Strikingly, while critical for the survival and coping capacity of the animal in a fluctuating environment, prolonged exposure to the HPA axis hormones is harmful and the dysregulation of the HPA axis is strongly implicated in a number of stress-induced disorders in humans including depression and anxiety disorders.
We are based in two locations: